Using sensitivity analysis and entropy production rate 10 main reactions, among 20 regulating the glycolysis process of AS-30D hepatoma and HeLa tumor cell line in stationary state, were identified. In fact, these 10 fundamental reactions are potential targets in cancer therapy. A high correlation between entropy production rate and intracellular pHi was detected in this work.
Montero S, Martin RR, Guerra A, Casanella O, Cocho G and Nieto-Villar JM
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